There should be no problems with 24/7 use. We have personally had a few of these plugged in for a few years now running 24/7 and haven’t noticed any problems. The V2 has 2 noise generators that are mixed together, even if one was to fail, the other would still be generating enough random data to carry it, if they both were to fail they would theoretically fail in different ways and the mixing of the two could still produce good entropy, we have tested this by artificially causing a generator to fail… and at the end of the spectrum if you are using RNGD, it will be running fips 140-2 on the incoming stream before entropy is inserted in the kernel. I hope this helps.